Found 59 results
A chemical genetics analysis of the roles of bypass polymerase DinB and DNA repair protein AlkB in processing N2-alkylguanine lesions in vivo. PLoS One 9, e94716 (2014).
CometChip: A High-throughput 96-Well Platform for Measuring DNA Damage in Microarrayed Human Cells. J Vis Exp (2014). doi:10.3791/50607
Direct observation of multiple tautomers of oxythiamine and their recognition by the thiamine pyrophosphate riboswitch. ACS Chem Biol 9, 227-36 (2014).
Efficient CRISPR-Cas9-mediated genome editing in Plasmodium falciparum. Nat Methods 11, 915-8 (2014).
Mechanism of repair of acrolein- and malondialdehyde-derived exocyclic guanine adducts by the α-ketoglutarate/Fe(II) dioxygenase AlkB. Chem Res Toxicol 27, 1619-31 (2014).
Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry. Nat Protoc 9, 828-41 (2014).
Rosa26-GFP direct repeat (RaDR-GFP) mice reveal tissue- and age-dependence of homologous recombination in mammals in vivo. PLoS Genet 10, e1004299 (2014).
Spatiotemporal intracellular nitric oxide signaling captured using internalized, near-infrared fluorescent carbon nanotube nanosensors. Nano Lett 14, 4887-94 (2014).
Tailoring chimeric ligands for studying and biasing ErbB receptor family interactions. Angew Chem Int Ed Engl 53, 2662-6 (2014).
Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2'-deoxycytidine. Proc Natl Acad Sci U S A 111, E3252-9 (2014).
Versatile control of Plasmodium falciparum gene expression with an inducible protein-RNA interaction. Nat Commun 5, 5329 (2014).
Antigenically intact hemagglutinin in circulating avian and swine influenza viruses and potential for H3N2 pandemic. Sci Rep 3, 1822 (2013).
Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease. Proc Natl Acad Sci U S A 110, E2332-41 (2013).
Comparative analysis of four oxidized guanine lesions from reactions of DNA with peroxynitrite, singlet oxygen, and γ-radiation. Chem Res Toxicol 26, 195-202 (2013).
DNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis. PLoS Pathog 9, e1003419 (2013).
The extracellular matrix Component Psl provides fast-acting antibiotic defense in Pseudomonas aeruginosa biofilms. PLoS Pathog 9, e1003526 (2013).
Glycan receptor binding of the influenza A virus H7N9 hemagglutinin. Cell 153, 1486-93 (2013).
Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis. Genes Dev 27, 1089-100 (2013).
In vivo biosensing via tissue-localizable near-infrared-fluorescent single-walled carbon nanotubes. Nat Nanotechnol 8, 873-80 (2013).
Increased levels of inosine in a mouse model of inflammation. Chem Res Toxicol 26, 538-46 (2013).
An integrated strategy for efficient vector construction and multi-gene expression in Plasmodium falciparum. Malar J 12, 373 (2013).
A multidimensional platform for the purification of non-coding RNA species. Nucleic Acids Res 41, e168 (2013).
Phosphotyrosine profiling of NSCLC cells in response to EGF and HGF reveals network specific mediators of invasion. J Proteome Res 12, 1856-67 (2013).
Recognition of heparan sulfate by clinical strains of dengue virus serotype 1 using recombinant subviral particles. Virus Res 176, 69-77 (2013).
Redesign of a cross-reactive antibody to dengue virus with broad-spectrum activity and increased in vivo potency. Proc Natl Acad Sci U S A 110, E1555-64 (2013).
Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors. Cell Cycle 12, 907-15 (2013).
Standard fluorescent imaging of live cells is highly genotoxic. Cytometry A 83, 552-60 (2013).
Structural determinants for naturally evolving H5N1 hemagglutinin to switch its receptor specificity. Cell 153, 1475-85 (2013).
AFB(1) -induced mutagenesis of the gpt gene in AS52 cells. Environ Mol Mutagen 53, 567-73 (2012).
Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA. Proc Natl Acad Sci U S A 109, 2319-24 (2012).
Direct and specific chemical control of eukaryotic translation with a synthetic RNA-protein interaction. Nucleic Acids Res 40, e64 (2012).
DNA repair is indispensable for survival after acute inflammation. J Clin Invest 122, 2680-9 (2012).
Enteric infection with Citrobacter rodentium induces coagulative liver necrosis and hepatic inflammation prior to peak infection and colonic disease. PLoS One 7, e33099 (2012).
Harnessing glycomics technologies: integrating structure with function for glycan characterization. Electrophoresis 33, 797-814 (2012).
Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer. Proc Natl Acad Sci U S A 109, E1820-9 (2012).
Integrated molecular analysis indicates undetectable change in DNA damage in mice after continuous irradiation at ~ 400-fold natural background radiation. Environ Health Perspect 120, 1130-6 (2012).
O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation. Integr Biol (Camb) 4, 1237-55 (2012).
Serum metabolomics in a Helicobacter hepaticus mouse model of inflammatory bowel disease reveal important changes in the microbiome, serum peptides, and intermediary metabolism. J Proteome Res 11, 4916-26 (2012).
A single neonatal exposure to aflatoxin b1 induces prolonged genetic damage in two loci of mouse liver. Toxicol Sci 128, 326-33 (2012).
17β-estradiol and tamoxifen prevent gastric cancer by modulating leukocyte recruitment and oncogenic pathways in Helicobacter pylori-infected INS-GAS male mice. Cancer Prev Res (Phila) 4, 1426-35 (2011).
Aflatoxin B1-DNA adduct formation and mutagenicity in livers of neonatal male and female B6C3F1 mice. Toxicol Sci 122, 38-44 (2011).
Combined confocal Raman and quantitative phase microscopy system for biomedical diagnosis. Biomed Opt Express 2, 2484-92 (2011).
Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes. J Biol Chem 286, 27729-40 (2011).
A microfabricated deformability-based flow cytometer with application to malaria. Lab Chip 11, 1065-73 (2011).
p53 null fluorescent yellow direct repeat (FYDR) mice have normal levels of homologous recombination. DNA Repair (Amst) 10, 1294-9 (2011).
Site-specific and redox-controlled S-nitrosation of thioredoxin. Proc Natl Acad Sci U S A 108, E600-6 (2011).
Chinese hamster ovary cells can produce galactose-α-1,3-galactose antigens on proteins. Nat Biotechnol 28, 1153-6 (2010).
CXCR6, a newly defined biomarker of tissue-specific stem cell asymmetric self-renewal, identifies more aggressive human melanoma cancer stem cells. PLoS One 5, e15183 (2010).